Hypertension due to high salt intake linked with emotional, cognitive dysfunction

New Delhi: A new study has linked hypertension, brought about by high salt intake, with emotional and cognitive dysfunction.

The study from Fujita Health University, Japan, found high salt intake to contribute to unwanted signalling between blood pressure regulation system and certain lipid molecules, thereby causing dysfunction in the brain.

Cognitive impairment has been linked to the consumption of excess table salt, a ubiquitous food seasoning. High salt (HS) intake is also known to lead to hypertension.

Dementia is described as a loss of cognitive functioning, which included thinking, remembering, and reasoning, and it is quite common in Japan. At the moment, treatment satisfaction for dementia is among the lowest, and no medication therapy to cure the condition is available. With the world’s population increasingly ageing, the discovery of dementia prevention and treatment medications is crucial.

To this end, a recent study published in the British Journal of Pharmacology thoroughly evaluated the aspects of HS-mediated hypertension and emotional/cognitive impairment. The study was performed by a team of collaborating researchers from Japan, and has shown how hypertension, mediated by the crosstalk between Ang II-AT1 and PGE2-EP1 causes emotional and cognitive dysfunction.

Author Hisayoshi Kubota from Fujita Health University’s Graduate School of Health Science comments, “Excessive salt intake is considered a risk factor for hypertension, cognitive dysfunction, and dementia. However, studies focusing on the interaction between the peripheral and central nervous system have not sufficiently investigated this association.”

According to the published data, the addition of excessive phosphates to the protein “tau” is primarily responsible for this emotional and cognitive consequences. The findings are particularly noteworthy because tau is a key protein of the Alzheimer’s disease.

The team first loaded laboratory mice with an HS solution (2 per cent NaCl in drinking water) for 12 weeks and monitored their blood pressure. “The effects of HS intake on emotional/cognitive function and tau phosphorylation were also examined in two key areas of the mouse brain–the prefrontal cortex and the hippocampus,” explains Prof. Mouri. Next, they also studied the involvement of the Ang II-AT1 and PGE2-EP1 systems in the HS-induced hypertension and neuronal/behavioral impairment.

The results were remarkable and encouraging: The brains of the experimental mice had several biochemical alternations. At the molecular level, besides the addition of phosphates to tau, the researchers also observed a decrease in the phosphate groups linked to a key enzyme called “CaMKII”–a protein involved in brain signaling. Moreover, changes in the levels of “PSD95”–a protein that plays a vital role in the organization and function of brain synapses (connection between brain cells)–were also evident. Interestingly, the biochemical changes were reversed after the administration of the antihypertensive drug “losartan.” A similar reversal was observed after knocking out the EP1 gene.

Overall, these findings suggest that angiotensin II-AT1 and prostaglandin E2-EP1 systems could be novel therapeutic targets for hypertension-induced dementia.